Preclinical assessment and randomized Phase I study of CT-P63, a broadly neutralizing antibody targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Article Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome Beta Blood caused clinically Concentration coronavirus COVID-19 creatine phosphokinase CT-P63 deaths declining Delta demonstrated detectable dose double-blind evaluated groups healthy volunteer Immunity in vitro in vivo Infection Infectious virus lung monoclonal monoclonal antibody morbidity and mortality mutated variant Neutralizing Neutralizing activity neutralizing antibody neutralizing antibody. omicron pandemic parallel-group participant peaked phase Placebo placebo-controlled Preclinical prevalent Prophylactic Randomized reduced respiratory tract Safe SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants of concern Serious Adverse Events significantly single ascending dose study drug TEAE titre Tolerability Transgenic mouse treated Treatment treatment-emergent adverse event vaccination variants variants of SARS-CoV-2 wild-type [DOI] 10.1080/22221751.2022.2117094 PMC 바로가기
SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial CellsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] Activation Adaptive immune response association biochemical Caco2 caused changed chemokine Colon contributed COVID-19 cytokine declining Delta delta variant disease epithelial cell line evade Evolution expected fatality feature highlighting Host Human humans IFN IFN response Infection Innate innate antiviral innate immune response interferon Intervention mechanism multiple mechanism outcome pandemic pathophysiology pathway persistence receptor reduced Replication response resulting RLR pathway robust SARS-CoV-2 SARS-CoV-2 variant severe disease Severe infection severe symptom silent susceptible sustained the disease transcriptomic Treatment vaccination variant variants variants. viral evolution virulence virus with COVID-19 [DOI] 10.1128/spectrum.01604-22 PMC 바로가기
Longitudinal cellular and humoral immune responses after triple BNT162b2 and fourth full-dose mRNA-1273 vaccination in haemodialysis patientsArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] ACE2 binding addition administration analysed anti-RBD B.1 binding BNT162b2 boost immunity cellular Control controls COVID-19 COVID-19 vaccination Decline declining Delta detectable dialysis dose doses group Haemodialysis Haemodialysis patient humoral humoral immune response Humoral immunity IgG IgG response immune immune evasion immune protection immunoassays Immunocompromised individual individuals information interferon γ knowledge longitudinal longitudinal response maintain mixed mRNA vaccination mRNA mRNA vaccination mRNA-1273 mucosal omicron Omicron variant of concern Patient patients Prevent protective immunity protective immunity. RBD reached regimen remained respond poorly restored SARS-CoV-2 vaccination SARS-CoV-2 variant second vaccination severe COVID-19 significantly increased spike subsequent Support T-cell Response tested the receptor-binding domain vaccination Vaccine variant variants of concern [DOI] 10.3389/fimmu.2022.1004045 PMC 바로가기
A cross-sectional national investigation of COVID-19 outbreaks in nurseries during rapid spread of the Alpha (B.1.1.7) variant of SARS-CoV-2 in EnglandArticle Published on 2022-10-022022-11-16 Journal: BMC Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] 95%CI affected Alpha variant B.1.1.7 children Community Complete COVID-19 outbreak cross-sectional cumulative declining Educational settings England Epidemiology Evidence highest highlighting incidence incidence rate index case infections investigated laboratory-confirmed lockdown National nurseries nursery Older outbreak Outbreaks PHE questionnaire remained reported risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2. Schools Spread Transmissibility variant of SARS-CoV-2 [DOI] 10.1186/s12889-022-14228-z PMC 바로가기
Impact of the COVID-19 Pandemic on Colorectal Cancer Screening: a Systematic ReviewArticle Published on 2022-09-012022-11-16 Journal: Journal of gastrointestinal cancer [Category] SARS, 치료기술, [키워드] Abstract activity article Cancer Care Colorectal Colorectal cancer Combination compensating country COVID-19 COVID-19 crisis COVID-19 pandemic declining decrease disease duplicates effective intervention eligible fit global pandemic Health hospital immunochemical Impact Infection investigated lack less maintain Mortality performed prevalence of COVID-19 prevalent reduce reduction in resource respiratory review Screening selected Surveillance systematic review. Web of Science were used WHO World Health Organization [DOI] 10.1007/s12029-021-00679-x PMC 바로가기
Glucocorticoids’ treatment impairs the medium-term immunogenic response to SARS-CoV-2 mRNA vaccines in Systemic Lupus Erythematosus patientsArticle Published on 2022-08-302022-11-15 Journal: Scientific Reports [Category] SARS, 진단, [키워드] administration Analysis Complete cross-sectional declining decrease evaluate groups help highest immunogenic immunosuppressive drug impacted impair individual Limited Lupus mRNA mRNA vaccine neutralizing antibody Patient patients protocol recommendation reduction in regimen Rheumatic diseases rituximab SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SLE SLE patient SLE patients subject systemic therapy titre treated Treatment vaccination Vaccine [DOI] 10.1038/s41598-022-18996-x PMC 바로가기
Effects of the Coronavirus Disease 2019 Pandemic on Human Immunodeficiency Virus Services: Findings from 11 Sub-Saharan African Countries코로나바이러스 질병 2019 팬데믹이 인간 면역결핍 바이러스 서비스에 미치는 영향: 사하라 사막 이남의 11개 아프리카 국가의 결과Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] 치료제, [키워드] Africa African analyzed Antiretroviral therapy ART change conducted coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 crisis COVID-19 pandemic declined declines declining decrease delivery of healthcare. Effect examined finding Health health facilities Health services healthcare HIV HIV testing Human Human immunodeficiency virus immunodeficiency virus increase Increases initial initiated Measures New no decrease pandemic rebound receiving Resilience SARS-CoV-2 sub-Saharan Africa tested Viral load VL testing [DOI] 10.1093/cid/ciab951 PMC 바로가기 [Article Type] Article
The burden of monkeypox virus amidst the Covid-19 pandemic in Africa: A double battle for AfricaShort communication Published on 2022-08-012022-10-05 Journal: Annals of Medicine and Surgery [Category] 치료기술, [키워드] Africa2 African caused clinical symptom contagious contributing to country COVID-19 COVID-19 cases Critical cross-protective immunity declining disease Disease surveillance Diseases effort fatigue Fever General population headache healthcare facility healthcare professionals Healthcare system impacted include inoculated International knowledge lack less Monkeypox Monkeypox virus MOST one health pandemic Rash risk Still Surveillance Symptom the disease Treatment vaccination Vaccine viral disease virus WHO zoonotic [DOI] 10.1016/j.amsu.2022.104197 [Article Type] Short communication
Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?COVID-19의 장기 발현: 부검을 통해 지금까지 (뿐만 아니라) 무엇을 배웠습니까?Review Published on 2022-08-012022-09-11 Journal: Virchows Archiv [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Acute kidney damage alveolar alveolar damage analytical methods Antithrombotic applicability Autopsies Autopsy cells change characterized clinical Combination conditions COVID-19 COVID-19 pandemic declining diffuse Diffuse alveolar damage direct infection disease Endothelial dysfunction explained immune response International Intussusceptive angiogenesis kidney limitation majority manifestation mechanism mechanisms morphological feature morphological features National nonspecific open organ organ injury organs pathological change pathological changes pathologist pathophysiology question recommendation Research SARS-CoV-2 SARS-CoV-2. supported thrombosis tissue tissue tropism tissues Treatment turn variants variants of concern vascular inflammation vasoconstriction [DOI] 10.1007/s00428-022-03319-2 PMC 바로가기 [Article Type] Review
Transitioning from Intravenous to Subcutaneous Vedolizumab in Patients with Inflammatory Bowel Disease [TRAVELESS]염증성 장 질환 환자에서 정맥 주사에서 피하 베돌리주맙으로 전환 [TRAVELESS]Article Published on 2022-07-142022-09-12 Journal: Journal of Crohn's & colitis [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adverse drug reactions appear baseline benefit biochemical bowel calprotectin clinically Cohort cohort of patients declining Disease activity dose effective evaluate expected Health Service IBD increase in Inflammatory bowel disease injection intravenous measure offered outcome Patient Patient satisfaction reaction reason reduction reported risk factor routine clinical care Safe SARS-COV-2 infection statistically significant statistically significant difference Subcutaneous switching TRAVELESS Treatment unlikely vedolizumab vedolizumab. Week [DOI] 10.1093/ecco-jcc/jjab224 PMC 바로가기 [Article Type] Article